alex compton nih

Freed, Ph.D. John M. Coffin, Ph.D. Alex Compton, Ph.D. Wei-Shau Hu, Ph.D. Stephen H. Hughes, Ph.D. Mary Kearney, Ph.D. CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. Barr: Today is November 19, 2020, and I [Gabrielle Barr] have the pleasure of speaking to Dr. Alex Compton. More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins. Alex A Compton 1 , Timothée Bruel 2 , Françoise Porrot 2 , Adeline Mallet 3 , Martin Sachse 3 , Marine Euvrard 4 , Chen Liang 5 , Nicoletta Casartelli 2 , Olivier Schwartz 6 Affiliations 1 Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; CNRS URA 3015, Paris 75015, France. Shi G, Schwartz O, Compton AA. Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE. Department of Health and Human Services; National Institutes of Health; USA.gov Guoli Shi, Stosh Ozog, Bruce E. Torbett, and View ORCID Profile Alex A. Compton a HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute , Frederick, MD 21702; b Department of Immunology and Microbiology, The Scripps Research Institute , La Jolla, CA 92037 Since its incorporation into the HIV Dynamics and Replication Program in 2017, the Compton lab focuses on mechanisms of cell-intrinsic immunity and the strategies employed by HIV and emerging viruses to evade or overcome these immune barriers. Infection by SARS-CoV-2 generally causes mild symptoms but can lead to severe disease and death in certain populations, including the immunocompromised. In 2017, Dr. Compton joined the HIV Dynamics and Replication Program as Head of the Antiviral Immunity and Resistance Section. Research in this field, which relies increasingly on interdisciplinary approaches and bioinformatics, has demonstrated that the survival of single cells equates strongly with survival of the organism, and even of the population (or species) to which it belongs. Trier par citations Trier par année Trier par titre. CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. What people with cancer should know: https://www.cancer.gov/coronavirus. Citée par. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable file. The "cell-intrinsic" arm of innate immunity prevents virus replication in host cells by detecting virus invasion and interfering with the viral life cycle. View additional Principal Investigators in Cell Biology, View additional Principal Investigators in Genetics and Genomics, View additional Principal Investigators in Immunology, View additional Principal Investigators in Molecular Biology and Biochemistry, View additional Principal Investigators in Virology, This page was last updated on November 5th, 2020, Presidential Early Career Award for Scientists and Engineers (PECASE), The American Academy of Arts and Sciences, National Medal of Technology & Innovation, Samuel J. Heyman Service to America Medals, Advancing Computational and Structural Biology, Uncovering New Opportunities for Natural Products, Unlocking the Potential of RNA Biology and Therapeutics, Tenure-track or Tenure-eligible Investigator, NLM, Nurturing the Next Generation of Clinical Researchers. Alex Compton (NIH/NCI) and Sergi Padilla-Parra (University of Oxford). alex.compton@nih… Articles Citée par Accès public. Alex Compton (NCI/NIH); Sergi Padilla-Parra (University of Oxford) Research Description: My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches. As such, cell-intrinsic immune factors, also known as host restriction factors, impose the earliest-acting barriers to invading pathogens. These studies provide important insight into the complex ways in which mammalian cells have evolved to counteract viral infections. The Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science. 2019;134(16):1298-1311. HIV DRP Retroviral Replication Laboratory, HIV Dynamics and Replication Program, Building 535, Room 307 Drug repurposing efforts are underway to identify compounds that interfere with SARS-CoV-2 replication or the immunopathology it can elicit. About Our Program. Since work on this project begun in February 2017, we have generated a large panel of novel IFITM3 mutants to aid our study. Rapamycin is among those being currently tested in clinical … alex.compton@nih.gov. 2020 Intramural AIDS Research Fellowships. Alex Compton (NCI/NIH); Sergi Padilla-Parra (University of Oxford) Research Description: My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches. Compton was the recipient of a Pasteur Foundation Postdoctoral Fellowship and an ANRS (French National Agency on AIDS Research) Grant during his postdoctoral training with Dr. Olivier Schwartz at the Pasteur Institute in Paris, where he made key discoveries on the mechanisms by which the interferon-induced transmembrane (IFITM) proteins restrict HIV-1 … Epub 2016 Sep 6. The Antiviral Immunity and Resistance Section, led by Alex Compton, focuses on mechanisms of protection mediated by the cell-intrinsic innate immune response, as well as the strategies employed by HIV and emerging viruses to evade or overcome these immune barriers. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. A live-streamed and archived videocast of the conference will be available on the NIH Videocast website at https://bit.ly/2GWDsg0. 3 HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702; alex.compton@nih.gov. Nonetheless, the goals and objectives of … Share Your Experience. Overall, cell-intrinsic immunity acting on membranes performs dual antiviral functions by 1) preventing virus infection of individual cells, and 2) limiting the spread of virus between cells. Behind the Mask Interview. FIG 1 IFITM2 and IFITM3 inhibit MLV infectivity and decrease Env levels in virus-producing cells. SIG Entity Reference: NIH Virology Scientific Interest Group (NIH VIG) PI Name: Alex Compton. Research Interests: HIV persistence, HIV Reservoir, Virus-Host Interaction U.S. Department of Health and Human Services     |     National Institutes of Health     |     National Cancer Institute     |     USA.gov, Home  |  Contact  |  Policies  |  Accessibility  |  Viewing Files  |  FOIA, Antiviral Immunity and Resistance Section, HIV DRP, NIH Virology Scientific Interest Group (NIH VIG), U.S. Department of Health and Human Services. mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Mentors: Dr. Alex Compton (NCI) & Dr. Sergi Padilla-Parra (Oxford) Degrees: Western Kentucky University, B.S. Interferon-induced transmembrane proteins (IFITMs) restrict infections by many viruses, but a subset of IFITMs enhance infections by specific coronaviruses through currently unknown mechanisms. Signals regulating the intrinsic antiviral state: stress, metabolism, differentiation, and activation. Citée par. The program focused on community partnerships and the importance of building the capacity of current and future generations of HIV researchers and advocates. Alex Compton (NCI/NIH); Sergi Padilla-Parra (University of Oxford) Research Description: My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable file. Because the APOBEC and IFITM proteins restrict the replication of a number of viruses in addition to HIV, this work has broad implications for the understanding of host-pathogen interactions. (B) Same as in panel A, except that xenotropic Env was used. in Biology and Chemistry (minor in Music), 2014; University College London, M.Sc. COVID-19 is an emerging, rapidly evolving situation. PI E-Mail: alex.compton@nih.gov Frederick, MD 21702-1201, Improving Human Antiviral Immunity, One Cell at a Time. Proc Natl Acad Sci U S A. Retrovirology. The HIV Dynamics and Replication Program (HIV DRP) was formed in 1997 as the HIV Drug Resistance Program, with the mission of conducting and fostering multidisciplinary basic, translational, and clinical research focused on problems related to drug-resistant HIV. NAME E-MAIL PHONE BLDG/ROOM; Compton Lab Compton, Alex, Ph.D. alex.compton@nih.gov: 301-846-7144: 535/307: Coomer, Charles, M.Sc. Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity. Blood. 2018;115(43):E10069-E10078. Get the latest public health information from CDC: https://www.coronavirus.gov. 2017;14(1):53. We invite you to explore the possibilities. Field of Interest: Virology, innate immunity, evolution. Chad is completing his MD/PhD degrees at the University of Kentucky (MD) and the University of Oxford (DPhil) under the mentorship of Drs. 2 HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA alex.compton@nih.gov. As a doctoral student in the laboratory of Dr. Michael Emerman (Fred Hutchinson Cancer Research Center), he investigated the HIV-1 Vif protein and its target APOBEC3G, revealing lentivirus-driven evolution of host proteins on a million-year time scale. NIH Oxford Scholar. Année; Since work on this project begun in February 2017, we have generated a large panel of novel IFITM3 mutants to aid our study. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. (A) 293T were cotransfected with env-deficient MLV (2.5 g), pBabeLuc (0.6 g), ecotropic Env (0.5 g), and empty pCMV6 or pCMV6-IFITM3 (0.03, 0.09, 0.27, or 0.81 g). Mechanisms of virus entry into cells and evasion of cell-intrinsic immunity HIV Dynamics and Replication Program Head, Antiviral Immunity and Resistance Section Work in the Antiviral Immunity and Resistance Section, led by Alex Compton, Ph.D., is guided by integrative approaches combining experimental virology, cell biology, and evolutionary biology to reveal dynamic host-virus interactions important for public health. The OAR hosted the NIH World AIDS Day observance on a virtual platform—the NIH VideoCast service—for the first time and simultaneously livestreamed the program for the public. Enhancement of virus delivery for gene editing in human cells and in vivo Trier. Alex Compton (NCI/NIH); Sergi Padilla-Parra (University of Oxford) Research Description: My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches. NIH VideoCasting. Titre. 3. Alex Compton, Ph.D. (NCI) Abstract Interferon-induced transmembrane protein 3 (IFITM3) is a critical component of the cell-intrinsic immune response to respiratory pathogens such as Influenza A virus. (3)HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702; alex.compton@nih.gov. *Corresponding author. We hope you will be able to join us on October 22! in Infection and Immunity, 2015. Here we show that SARS-CoV-2 Spike-pseudotyped virus and genuine SARS-CoV-2 infections are generally restricted by expression of human IFITM1, IFITM2, and … Since work on this project began in February 2017, we have made a number of key advancements. All work in my section began in February 2017, so there are no CCR-based accomplishments to report yet. Our preliminary work using rapamycin on transformed epithelial cell lines has … By combining relevant experimental systems in virology with perspectives in cell biology and evolutionary biology, we aim to better understand the factors governing virus entry into cells. National Cancer Institute (NCI/NIH) Adresse e-mail validée de nih.gov - Page d'accueil. Alex Compton, PhD. Dr. Alex Compton. 1. More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins. Cellular membranes, composed of proteins and lipids, are the first line of defense against infection. Get the latest research information from NIH: https://www.nih.gov/coronavirus. Shi G, Ozog S, Torbett BE, Compton AA. This website is part of the Office of NIH History and Stetten Museum’s documentation of the NIH’s role during the COVID-19 pandemic by capturing the professional and personal experiences of NIH government employees, contractors, trainees, and … An Intrinsic Link between the Metabolic and Antiviral States of the Cell Compton, Alex National Cancer Institute Division of Basic Sciences In addition to protecting cells from infection, cellular membrane components also impact the structure and infectivity of nascent virions produced from infected cells. EMBO Rep. 2016 Nov;17(11):1657-1671. We employ a “cross-species” approach, in which diverse viruses are paired with host cells of diverse species in order to reveal cell-intrinsic barriers that limit virus infection. mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Residents of this critical threshold include cellular transmembrane proteins that remodel membrane vesicles or redirect their trafficking in order to inhibit the viral entry process. Dr. Compton is the head of the Antiviral Immunity and Resistance Section of the HIV Dynamics and Replication Program at the National Cancer Institute (NCI). Current projects in the lab revolve around the following themes: 1. Alex Compton, Ph.D., National Cancer Institute. 4 Antiviral Immunity and Resistance Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. chad.coomer@nih.gov In 2020, 15 applications for the Intramural AIDS Research Fellowships were selected for funding from a large number of meritorious submissions. Dr. Compton was the recipient of a Pasteur Foundation Postdoctoral Fellowship and an ANRS (French National Agency on AIDS Research) Grant during his postdoctoral training with Dr. Olivier Schwartz at the Pasteur Institute in Paris, where he made key discoveries on the mechanisms by which the interferon-induced transmembrane (IFITM) proteins restrict HIV-1 infection. NIH VideoCasting. Tel: +1 614 688 1639; E-mail: Jacob.Yount@osumc.edu †These authors contributed equally to this work ‡This article has been contributed to by US Government employees and their work is in the public domain in the USA The clinical outcome of viral infection, the difference between survival and death of the host, rests delicately on events occurring at the molecular level of individual cells. Rapamycin and its derivatives are specific inhibitors of mammalian target of rapamycin (mTOR) kinase and, as a result, are well-established immunosuppressants and antitumorigenic agents. CIT can also broadcast NIH-only or HHS-only content. November 19, 2020. 2. Dr. Alex Compton received his Ph.D. in Molecular and Cellular Biology from the University of Washington in 2012. Evolution of innate immunity host-virus interactions. Organizing Committee: Eric O. Work in the Antiviral Immunity and Resistance Section, led by Alex Compton, Ph.D., is guided by integrative approaches combining experimental virology, cell biology, and evolutionary biology to reveal dynamic host-virus interactions important for public health. Tel: +1 301 846 7144; E-mail: alex.compton@nih.gov **Corresponding author. And advocates 11 ):1657-1671 barriers to alex compton nih pathogens world-wide audience over the Internet as a real-time video... Revolve around the following themes: 1 at endosomes, innate immunity,.! And I [ alex compton nih barr ] have the pleasure of speaking to Dr. Alex Compton received his Ph.D. Molecular... Embo Rep. 2016 Nov ; 17 ( 11 ):1657-1671 Institute ( NCI/NIH Adresse. 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