Management of sepsis and septic shock 1. Get ideas for your own presentations. Dept. Accounts for ~20 percent of U.S. hospital admissions but is a factor in over 50 percent of U.S. hospital deaths. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Initial evaluation of patients with suspected sepsis includes basic laboratory tests, cultures, imaging studies as indicated, and sepsis biomarkers such as procalcitonin and lactate levels. Sepsis Background and Significance • Sepsis affects >750,000 American and >1.8 million patients worldwide per year. SIRS• Two or more of the following conditions:– Fever or hypothermia– Tachypnea– Tachycardia– Leukocytosis or leukopenia or >10% bands• Infectious / Noninfectious6 7. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Septicemia 1. fcps-ii trainee cmc larkana 2. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Earlyrecognition and diagnosis ofsepsis is required to prevent the transition into septic shock,which is associated with a mortality rate of 40% or more. There has been no magic bullet for the management of sepsis. of Neurology GMC Kota. See our Privacy Policy and User Agreement for details. It is manifested by two or more of the SIRS (Systemic Inflammatory Response Syndrome) criteria as a consequence of documented or presumed infection. 3 4. This article reviews guidance on the di-agnosis and management of sepsis and septic shock, with attention to maximizing adher-ence to best practice statements, and contro-versies in defi nitions, diagnostic criteria, and management. Sepsis is a life-threatening organ dysfunction that results from the body’s response to infection. life-threatening organ dysfunction caused by a dysregulated host response to infection In patients with septic shock, the administration of fluids during initial hemodynamic resuscitation remains a major therapeutic challenge. Sepsis 2018: Definitions and Guideline Changes Lena M. Napolitano Abstract Background: Sepsis is a global healthcare issue and continues to be the leading cause of death from infection. Looks like you’ve clipped this slide to already. International Guidelines for See our User Agreement and Privacy Policy. (Neviere, 2014). Learn new and interesting things. View Septicemia PPTs online, safely and virus-free! Septicemia international management guideline. 1,2 This is one of the deadliest conditions treated in children. • The program co-sponsors do not endorse Looks like you’ve clipped this slide to already. Management of sepsis and meningitis in developing countries, Management of severe sepsis & septic shock f, The Sepsis Resuscitation And Management Bundles, No public clipboards found for this slide. If you continue browsing the site, you agree to the use of cookies on this website. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Over 50% of sepsis cases is caused by gram-positive organisms; therefore, gram-positive bacteria are the predominant cause of sepsis. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Septicemia• Presence of microbes or toxins in blood5 6. 1 Sepsis is a leading cause of death, morbidity, and expense, contributing to one-third to half of deaths of hospitalized patients, 2 depending on definitions. Enumerates the latest advancements in the management of sepsis and the search into its pathophysiology. Key Concepts of Sepsis o Sepsis is the primary cause of death from infection, especially if not recognized and treated promptly. You can change your ad preferences anytime. Obtain blood cultures prior to administration of antibiotics 3. If you continue browsing the site, you agree to the use of cookies on this website. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. TO BE COMPLETED WITHIN 3 HOURS OF TIME OF PRESENTATION: 1. If you continue browsing the site, you agree to the use of cookies on this website. Bacterial sepsis following pregnancy in the puerperium is the subject of a separate Green-top Guideline. Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Shock Management of Sepsis and SIRS Martin D. Black, MD. The population covered by … Background: In 2004, the Surviving Sepsis Campaign (SSC), a global initiative to reduce mortality from sepsis, was launched. Management of Sepsis & Septic Shock International Guidelines Dr. Samaresh Das 2. See our User Agreement and Privacy Policy. Just as in adults, pediatric sepsis is a complex topic with continued research.In the United States, there are an estimated 75,000 cases per year of pediatric severe sepsis with an in-hospital mortality of 5-10%. Untreated it can result in sepsis, a life-threatening inflammation. Share yours for free! MANAGEMENT OF SEPSIS AND One of the most common types of circulatory shock and the incidences of this disease continue to rise despite the technology. Senior Resident Infection • Invasion of normally sterile host tissue by microorganisms 4 5. International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 10. Sepsis arising due to viral, fungal or other infectious agents is outside the scope of this guideline. Affecting an estimated 30 million adults and children each year resulting in potentially six million deaths annually. Clipping is a handy way to collect important slides you want to go back to later. Administer broad spectrum antibiotics 4. Fluid resuscitation is the priority in early management, including administering an intravenous crystalloid at 30 mL per kg within the first three hours. 2. Now customize the name of a clipboard to store your clips. Dr. Ankur Gupta. 1. International Guidelines for Management of Sepsis and Septic Shock Dr. Sunil Kumar Sharma Senior Resident Dept. Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the management and treatment of patients and for the development of potential new therapies. It requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection. • US hospital costs for sepsis are >$17 billion, with an uptrend of ~12%/year • Severe forms of sepsis require ICU care – Measure lactate level 2. Septicemia 1. of Neurology Abstract. Septicemia international management guideline. Mechanical Ventilation of Sepsis induced ARDS • Target TV 6 ml/kg predicted body weight • Head end of bed 30-45 ° elevated • Plateau pressures initial upper limit goal in passively inflated lung ≤ 30 cm water • Apply PEEP • For Severe Hypoxemia: use recruitment maneuvers • Prone Positioning: PaO2/FiO2 ratio ≤ 100 mm Hg • In absence of specific indications (bronchospasms) DONOT use beta-2 agonists in sepsis … If you continue browsing the site, you agree to the use of cookies on this website. Dr. Sunil Kumar Sharma management of sepsis and septic shock dr. ankur gupta Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. •Hospital-wide sepsis management protocols targeting the identification and treatment of severe sepsis has demonstrated mortality benefit. 1. Early involvement of critical care services 8. Bacteremia- Presence of bacteria in blood, as evidenced by positive blood cultures Septicemia- Presence of microbes or their toxins in blood Systemic inflammatory response syndrome … are critical. Administer 30ml/kg crystalloid for hypotension or lactate ≥4mmol/L . 1. management in secondary care. Early initiation of inotropes 7. Sepsis• SIRS with proven or suspected microbialetiology7 8. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. DISCLOSURES • There has been no commercial support or sponsorship for this program. Septicemia is a bacterial infection spread through the entire vascular system of the body. Sepsis is a systemic response to infection. Sepsis remains a significant burden on health systems worldwide. World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. In clinical practice, six major organ systems - the cardiovascular (including the microcirculation), respiratory, renal, … Many are downloadable. But recognizing sepsis can be a challenge, and best management practices continue to evolve. • Sepsis accounts for >200,000 deaths each year in the United States. diabetes mellitus presents with a three-day history of fever, chills, left-side flank pain, and dysuria. SEPTIC SHOCK Successful treatment of two cases of Elizabethkingia meningoseptica septicemi... 12 bio265 disease of circulatory system instructor dr di bonaventura, Protocol and guideline in critical care ppt, No public clipboards found for this slide. Septic shock is sepsis that results in tissue hypoperfusion, with vasopressor-requiring hypotension and elevated lactate levels. If you continue browsing the site, you agree to the use of cookies on this website. Elizabeth Muñoz Medicina 2012 Cirugía 2. However, the advances made in understanding its pathogenesis and the extensive efforts at framing guidelines for its effective management in the last 20 years exceed anything that has been done before. Although the SSC supplies tools to measure and improve the quality of care for patients with sepsis, effective implementation remains troublesome and no recommendations concerning the role of nurses are given. Sepsis is a major, world-wide health care problem . We are faced with many open questions regarding the type, dose and timing of intravenous fluid administration. Now customize the name of a clipboard to store your clips. [healthcentral.com] GMC Kota. Severe sepsis and septic shock are the major healthcare problem with high mortality and increasing incidence. 1. [slideshare.net] When hypotension (low blood pressure) and signs of inadequate organ perfusion develop, the condition is termed septic shock. The respiratory system is the most common site of infection. Bacterial Sepsis: Practice Essentials, Background, Etiology bed.10,11 Some ofthe new approaches to management severe sepsis and septic shock appear to be time dependent, suggesting a “golden hour” and “silver day”12 perspective to the management of this disorder, giving the ED a more important role in the care of these patients. Resuscitate the patient, using supportive measures to correct hypoxia, hypotension, and impaired tissue oxygenation (hypoperfusion) Most cases of septic shock are caused by gram-negative bacilli or gram-positive cocci. See our Privacy Policy and User Agreement for details. • The planners and presenters have declared that no conflicts of interest exist. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. 2. Management of Sepsis and Septic Sepsis is caused by a wide variety of microorganisms, including gram-negative and gram-positive aerobes, anaerobes, fungi, and viruses. The Management of Severe Sepsis and Septic Shock MatthewR.Morrell,MDa,*,ScottT.Micek,PharmDb,MarinH.Kollef,MDa Severe sepsis and septic shock persist as major health care problems despite ongoing research to improve overall outcomes. Clipping is a handy way to collect important slides you want to go back to later. Severe sepsis and septic shock in pregnancy. OUTLINES • Terminology • Etiology • Pathology • Clinical presentation • Complications • Investigations • Management • Prevention 3. Frequent reassessment References • Barton, J. R. & Sibai, B. M. (2012). Overall mortality from severe sepsis or septic shock ranges from 30% to 60% despite aggressive medical care … En Chile no se cuenta con estadísticas No se diagnostica no se reporta en las estadísticas hospitalarias Principal causa de muerte en UTIs Es una de las 10 primeras causas de mortalidad en los EUA En EUA 1995 existió 750,000 casos de sepsis por año de los cuales 250,000 fallecieron Management of hypotension• Vasopressor therapy– Titrating dose of norepinephrine or dopamine– Dobutamine if myocardial dysfunction28 29. Source control 9. Obstetrics & Gynecology, 120(3), 689-706. You can change your ad preferences anytime. Of death from infection, especially if not recognized and treated promptly the priority in early,... Many open questions regarding the type, dose and timing of intravenous fluid administration therapy–... To BE COMPLETED WITHIN 3 HOURS of TIME of presentation: 1 types. Or gram-positive cocci is sepsis that results in tissue hypoperfusion, with hypotension! 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